承担国家“973”组织⼯程研究⼦项目、国家“863”重⼤专项、国家自然科学基⾦等多项课题。以通讯（含共同）发表SCI论⽂65篇，包括Nature Communications, Journal of Clinical Investigation, Advanced Science, Biomaterials, Acta Biomaterials等⾼⽔平期刊。获授权发明专利15项。主笔《黄家驷外科学》中组织⼯程章节。作为专家组组长，主持制定了第⼀部组织⼯程技术临床应用管理规范，参与制定了多项组织⼯程产品国家标准。
中华⼈民共和国建国70周年国家纪念奖章获得者（中共中央、国务院、中央军委颁布）。获国家技术发明⼆等奖(第⼆完成⼈)、教育部科技进步⼆等奖(第⼀完成⼈)、上海市科技进步⼀等奖等奖等多种奖励。先后获北京市医管局“扬帆计划”、上海市“曙光学者”、“上海市优秀学科带头⼈”、上海市科委“启明星”、“启明星后”、全国优秀青年骨⼲教师等⼈才奖励计划及荣誉。
代表性论文:
1. Shuaijun Li, Ting Shang, Laiya Lu, Peisheng Jin, Qian Wang, Ruizhu Sun, Xin Zou, Haotian Han, Yubin Kang, Si Shi, Jiaxin Ren, Cheng Zhao, Jiefeng Huang, Feng Yin*, Yun Zhang*, Lei Cui*. Epigenetic mechanisms underlying glutamine deficiency-induced osteoarthritis. Accept. Journal of Clinical Investigation. (IF 13.6).
2. Jiefeng Huang, Ke Fang, Rongrong Wu,Wuyan Lu, Linxiao Li, Zixin Cai, Zihao Hu, Yu Jiang, Jinyi Deng, Zhuang Luo*, Lei Cui*, Shuaijun Li*. Homocysteine exacerbates pulmonary fibrosis via orchestrating syntaxin17 homocysteinylation of alveolar type II cells. Adv. Sci. 2025 Sep 24:e07803. (IF 14.1).
3. Ting Shang, Linxiao Li, Xiaohui Miao, Jieshen Huang, Yu Jiang, Wuyan Lu, Zixin Cai, Yishu Lu, Lei Cui, Hui Kang*, Shuaijun Li*, Jiefeng Huang*. Acetoacetate Ameliorates Skin Fibrosis by Modulating TGF-β1/Smad2/3 Signaling Pathway. J Bio Chem. 2025 Oct 27:110867. (IF 3.9).
4. Jiefeng Huang, Shuangmeng Jia, Yitong Ji, Fang Ke, Wuyan Lu, Lei Cui*, Shuaijun Li*. Alpha-ketoglutarate promotes random-pattern skin flap survival by enhancing angiogenesis via PI3K/Akt/HIF-1α signalling pathway. Cell Regeneration. Accepted. (IF 4.7).
5. Shuaijun Li, Cheng Zhao, Guoying Shang, Jun-Ling Xie, Lei Cui*, Qun Zhang*, Jiefeng Huang*. α-ketoglutarate preconditioning extends the survival of engrafted adipose-derived mesenchymal stem cells to accelerate healing of burn wounds. Exp Cell Res. 2024 Jun 1;439(1):114095. (IF 3.5).
6. Ren J, Zhao C, Sun R, Sun J, Lu L, Wu J, Li S, Cui L. Augmented drug resistance of osteosarcoma cells within decalcified bone matrix scaffold: The role of glutamine metabolism. Int J Cancer. 2024 May 1;154(9):1626-1638(IF:6.5，封⾯⽂章).
7. Can Wang, Qiannan Zhao, Xiaohong Zheng, et al. Decellularized brain extracellular matrix slice glioblastoma culture model recapitulates the interaction between cells and the extracellular matrix without a nutrient-oxygen gradient interference. Acta Biomater. 2023,158:132. (IF 10.6).
8. Yun Zhang, Shuaijun Li, Peisheng Jin, et al. Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis. Nat Commun. 2022;13:2447. (IF 17.7).
9. Xiaoyu Li, Peilin Li, Can Wang, et al. A Thermo-sensitive and Injectable Hydrogel Derived from Decellularized Amniotic Membrane to Prevent Intrauterine Adhesion by Accelerating Endometrium Regeneration. Biomater Sci. 2022 May 4;10(9):2275-2286. (IF: 6.2).
10. Haiqing Tian, Hejiang Zhang, Hong Qiu, et al. Influence of maternal age on the relationship between endometrial thickness and ongoing pregnancy rates in frozen-thawed embryo transfer cycles: a retrospective analysis of 2,562 cycles. Front Endocrinol (Lausanne). 2022 Apr 27:13:821753. (IF 5.6).
11. Qian Wang, Jiefeng Huang, Shuaijun Li, et al. Fermentation supernatant of Staphylococcus aureus drives catabolism in chondrocytes via NF-κB signaling mediated increase of cholesterol metabolism. Exp Cell Res. 2022,410(1):112952. (IF 3.4).
12. Li Y, Wang G, Wang Q, et al. Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia. J Immunol Res 2022 Feb 3;2022:7471246. (IF 4.5 ).
13. Guoying Zhang, Na Li, Yongjuan Tong, et al. Artemisinin derivatives inhibit adipogenic differentiation of 3T3-L1 preadipocytes through upregulation of CHOP.. Biochem Biophys Res Commun. 2021,557:309-315. (IF 2.985).
14. Chenxiao Zhou,Wanchun Su, Haotian Han, et al. Mouse tail models of secondary lymphedema: fibrosis gradually worsens and is irreversible. Int J Clin Exp Pathol. 2020,13(1):54-64. (IF 0.205).
15. Xing Chen, Jingtao Sun, Xiaoyu Li, et al. Transplantation of oral mucosal epithelial cells seeded on decellularized and lyophilized amniotic membrane for the regeneration of injured endometrium. Stem Cell Res Ther. 2019,10(1):107. (IF 5.1).
16. Shang T, Li S, Zhang Y, Lu L, Cui L, Guo FF. Hypoxia promotes differentiation of adipose-derived stem cells into endothelial cells through demethylation of ephrinB2. Stem Cell Res Ther. 2019 May 20;10(1):133. (IF 5.1).
17. Chen X, Sun J, Li X, Mao L, Zhou Y, Cui L, Bai W. Antifibrotic Effects of Decellularized and Lyophilized Human Amniotic Membrane Transplant on the Formation of Intrauterine Adhesion.Exp Clin Transplant. 2019 Apr;17(2):236-242. (IF 0.85).
18. Chen X, Sun J, Li X, Mao L, Cui L, Bai W. Transplantation of oral mucosal epithelial cells seeded on decellularized and lyophilized amniotic membrane for the regeneration of injured endometrium. Stem Cell Res Ther. 2019 Mar 21;10(1):107. (IF 5.1).
19. Huang Z, Gu H, Yin X, Gao L, Zhang K, Zhang Y, Xu J, Wu L, Yin J, Cui L. Bone regeneration using injectablepoly (γ-benzyl-L-glutamate) microspheres loaded with adipose-derived stem cells in a mouse femoral non-union model. Am J Transl Res. 2019 May 15;11(5):2641-2656. (IF 3.4).
20. Shuaijun Li, Yun Zhang, Yidan Sun, Weigang Cao,, Lei Cui. Exposure to fermentation supernatant of Staphylococcus aureus accelerated dedifferentiation of chondrocytes and production of antimicrobial peptides. J Orthop Res. 2018 Jan;36(1):443-451. (IF 2.7 .)
21. Ding Y, Cui L, Zhao Q, Zhang W, Sun H, Zheng L. Platelet-Rich Fibrin Accelerates Skin Wound Healing in Diabetic Mice. Ann Plast Surg. 2017 Sep;79(3):e15-e19. (IF: 1.4)
22. Gao L, Huang Z, Yan S, Zhang K, Xu S, Li G, Cui L, Yin J. Sr-HA-graft-Poly(γ-benzyl-l-glutamate) Nanocomposite Microcarriers: Controllable Sr2+ Release for Accelerating Osteogenenisis and Bony Nonunion Repair. Biomacromolecules. 2017 Nov 13;18(11):3742-3752. (IF 6.1).
23. Aimaiti A, Maimaitiyiming A, Boyong X, Aji K, Li C, Cui L. Low-dose strontium stimulates osteogenesis but high-dose doses cause apoptosis in human adipose-derived stem cells via regulation of the ERK1/2 signaling pathway. Stem Cell Res Ther. 2017 Dec 19;8(1):282. (IF 5.1).
24. Zhang K, Song L, Wang J, Yan S, Li G, Cui L, Yin J. Strategy for constructing vascularized adipose units in poly(l-glutamic acid) hydrogel porous scaffold through inducing in-situ formation of ASCs spheroids. Acta Biomater. 2017;51:246-257. (IF 7.2.)
25. Xue X, Liu Y, Wang Y, Meng M, Wang K, Zang X, Zhao S, Sun X, Cui L, Pan L, Liu S. MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1, SOCS6, and PTEN. Oncotarget. 2016 ; 7(51):84508-84519.
26. Yan S, Zhang X, Zhang K, Di H, Feng L, Li G, Fang J, Cui L#, Chen X, Yin J. Injectable in situ forming poly (Lglutamic acid) hydrogels for cartilage tissue engineering. J. Mater. Chem. B, 2016; 4: 947-961. (IF 5.3)
27. Zhang K, He S, Yan S, Li G, Zhang D, Cui L, Yin J. Regeneration of hyaline-like cartilage and subchondral bone simultaneously by poly- (L-glutamic acid) based osteochondral scaffolds with induced autologous adipose derived stem cells. J. Mater. Chem. B, 2016; 4: 2628-2645. (IF 5.3).
28. Kaisaier A, Munila M, Abudusaimi A, Cui L. Differentiation of human adipose derived stem cells into smooth muscle cells is modulated by CaMKII. Stem Cells International. Stem Cells Int, 2016 (19):1-9. (IF 3.9).
29. Li C, Bi W, Gong Y, Ding X, Guo X, Sun J, Cui L, Yu Y. Transforming growth factor-beta1 inhibits tissue engineering cartilage absorption via inducing the generation of regulatory T cells. J Tissue Eng Regen Med. 2016;10(2):E113-20. (IF: 3.1).
30. Gu H, Huang Z, Yin X, Lu L, Cui L. Role of c-Jun N-terminal kinase in the osteogenic and adipogenic differentiation of human adipose-derived mesenchymal stem cells. Exp Cell Res. 2015,339(1):112-21. (IF 3.4).
31. Jianjun Fang, Qi Yong, Kunxi Zhang,Wentao Sun, Shifeng Yan, Lei Cui and Jingbo Yin. Novel injectable porous poly(g-benzyl-L- glutamate) microspheres for cartilage tissue engineering: preparation and evaluation. J. Mater.Chem. B, 2015, 3, 1020–1031. (IF: 5.3)
32. Zhang K, Yan S, Li G, Cui L, Yin J. In-situ birth of MSCs multicellular spheroids in poly(L-glutamic acid)/ chitosan scaffold for hyaline-like cartilage regeneration. Biomaterials, 2015. 71: p24-34. (IF 10.3)
33. Fang J, Zhang Y, Yan S, Liu Z, He S, Cui L, Yin J. Poly(L-glutamic acid)/chitosan polyelectrolyte complex porous microspheres as cell microcarriers for cartilage regeneration. Acta Biomater. 2014 Jan;10(1):276-88. (IF 5.1)
34. Zhang K, Zhang Y, Yan S, Gong L, Wang J, Chen X, Cui L, Yin J. Repair of an articular cartilage defect using adipose-derived stem cells loaded on a polyelectrolyte complex scaffold based on poly(l-glutamic acid) and chitosan. Acta Biomater. 2013 Jul;9(7):7276-88. (IF 5.1)
35. Gong L, Zhou X, Wu Y, Zhang Y, Wang C, Zhou H, Guo F, Cui L. Proteomic analysis profile of engineered articular cartilage with chondrogenic differentiated adipose tissue-derived stem cells loaded polyglycolic acid mesh for weight-bearing area defect repair.Tissue Eng Part A. 2014 Feb;20(3-4):575-87. (IF 4.5)
36. Wang C et al, Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1α and VEGF expression.PLoS One. 2014. (IF: 3.5).
37. Zou J, et al. The graft of autologous adipose-derived stem cells in the corneal stromal after mechanic damage.PLoS One.2013. (IF 3.5).
38. Liu G, Zhang Y, Liu B, Sun J, Li W, Cui L. Bone regeneration in a canine cranial model using allogeneic adipose derived stem cells and coral scaffold. Biomaterials. 2013 Apr;34(11):2655-64. (IF 7.8)
39. Wang C, Guo F, Zhou H, Zhang Y, Xiao Z, Cui L. Proteomic profiling of tissue-engineered blood vessel walls constructed by adipose-derived stem cells. Tissue Eng Part A. 2013; 19:415-25. (IF 4.5)
40. 17.Shifeng Yan,Kunxi Zhang,Zhiwen Liu, Xin Zhang,Lu Gan,Bin Cao, Xuesi Chen,Lei Cui and Jingbo Yin. Fabrication of poly(L-glutamic acid)/chitosan polyelectrolyte complex porous scaffolds for tissue engineering. J. Mater. Chem. B, 2013, 1, 1541–1551. (IF: 5.3)
41. Xu J, Chen Y, Yue Y, Sun J, Cui L. Reconstruction of epidural fat with engineered adipose tissue from adipose derived stem cells and PLGA in the rabbit dorsal laminectomy model. Biomaterials. 2012 ;33(29):6965-73. (IF 7.8).
42. Chen F, Zhang W, Wu W, Jin Y, Cen L, Kretlow JD, Gao W, Dai Z, Wang J, Zhou G, Liu W, Cui L, Cao Y. Cryopreservation of tissue-engineered epithelial sheets in trehalose. Biomaterials. 2011 Nov;32(33):8426-35. (IF 7.8).
43. Gao WC, Ma SL, Cui L. Adipose-derived stem cells accelerate neovascularization in ischemic diabetic skin flap via expression of hypoxia-inducible factor-1. J Cell Mol Med. 2011;15:2575-85. (IF 4.5).
44. Gu H, Guo F, Zhou X, Gong L, Zhang Y, Zhai W, Chen L, Cen L, Yin S, Chang J, Cui L. The stimulation of osteogenic differentiation of human adipose-derived stem cells by ionic products from akermanite dissolution via activation of the ERK pathway. Biomaterials. 2011; 32:7023-33.(IF 7.8).
45. Cao B, Yan S, Zhang K, Song Z, Chen X, Cui L, Yin J. Layer-by-layer assembled multilayer films of methoxypoly (ethylene glycol)-block-poly(!,l-glutamic acid) and chitosan with reduced cell adhesion. Macromol Biosci. 2011;11:1211-7(IF: 3.2).
46. Yan S, Yin J, Cui L, Yang Y, Chen X. Apatite-forming ability of bioactive poly(l-lactic acid)/grafted silica nanocomposites in simulated body fluid.Colloids Surf B Biointerfaces. 2011;86(1):218-24.(IF 2.5).
47. Cao B, Yan S, Zhang K, Song Z, Cao T, Chen X, Cui L, Yin J. A poly (acrylic acid)-block-poly(L-glutamic acid) diblock copolymer with improved cell adhesion for surface modification. Macromol Biosci. 2011;11(7):970-7. (IF 4.3 ).
48. Cao B, Yin J, Yan S, Cui L, Chen X, Xie Y. Porous scaffolds based on cross-linking of poly(L-glutamic acid). Macromol Biosci. 2011;11(3):427-34(IF 4.3).
49. Yin S, Cen L, Wang C, Zhao G, Sun J, Liu W, Cao Y, Cui L. Chondrogenic transdifferentiation of human dermal fibroblasts stimulated with cartilage-derived morphogenetic protein 1. Tissue Eng Part A. 2010;16: 1633-43. (IF 4.5).
50. Yuan J, Zhang WJ, Liu G, Wei M, Qi ZL, Liu W, Cui L, Cao YL. Repair of canine mandibular bone defects with bone marrow stromal cells and coral. Tissue Eng Part A. 2010;16:1385-94. (IF 4.5).
51. Wang C, Yin S, Cen L, Liu Q, Liu W, Cao Y, Cui L.Differentiation of adipose-derived stem cells into contractile smooth muscle cells induced by transforming growth factor-beta1 and bone morphogenetic protein-4. Tissue Eng Part A. 2010;16:1201-13.(IF 4.5 )
52. Liu G, Li Y, Sun J, Zhou H, Zhang W, Cui L, Cao Y. In vitro and in vivo evaluation of osteogenesis of human umbilical cord blood-derived mesenchymal stem cells on partially demineralized bone matrix. Tissue Eng Part A. 2010;16:971-82. (IF 4.5).
53. Wang C, Cen L, Yin S, Liu Q, Liu W, Cao Y, Cui L. A small diameter elastic blood vessel wall prepared under pulsatile conditions from polyglycolic acid mesh and smooth muscle cells differentiated from adipose-derived stem cells. Biomaterials. 2010;31:621-30. (IF 7.8).
54. Wang HJ, Liu GP, Zhou GD, Cen L, Cui L, Cao Y. Comparative investigation of viability, metabolism and osteogenic capability of tissue-engineered bone preserved in sealed osteogenic media at 37 degrees C and 4 degrees C. BIOMEDICAL MATERIALS 2010; 5: 035010. (IF 1.8).
55. Liu Q, Cen L, Zhou H, Yin S, Liu G, Liu W, Cao Y, Cui L. The role of the extracellular signal-related kinase signaling pathway in osteogenic differentiation of human adipose-derived stem cells and in adipogenic transition initiated by dexamethasone. Tissue Eng Part A. 2009;15:3487-97. (IF 4.5).
56. Cui L, Wu YH, Cen L, et al. Repair of Articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh. Biomaterials. 2009; 30:2683-2693. (IF 7.8).
57. Zhao GQ, Yin S, Cen L, et al. In vitro engineering of fibrocartilage using CDMP1 induced dermal fibroblasts and polyglycolide. Biomaterials. 2009;30:3241-50. (IF 7.8 )
58. Lian Cen, Koon Gee Neoh, Jian Sun, et al. Labeling of adipose derived stem cells by oleic acid modified magnetic nanoparticles. Advanced Func.Mater.2009; 19: 1158-66.(IF: 9.6).
59. Liu Q, Cen L, Yin S,et al. A comparative study of proliferation and osteogenic differentiation of adiposederivedstem cells on akermanite and beta-TCP ceramics. Biomaterials. 2008; 29: 4792-4799. (IF: 7.8).
60. Luo K, Yin J, Song Z, et al. Biodegradable Interpolyelectrolyte Complexes Based on Methoxy Poly(ethylene glycol)-b-poly(alpha,l-glutamic acid) and Chitosan. Biomacromolecules. 2008; 9:2653-61. (IF: 5.1).
61. Liu G, Zhou H, Li Y, et al. Evaluation of the viability and osteogenic differentiation of cryopreserved human adipose-derived stem cells. Cryobiology. 2008; 57:18-24, (IF 2.8 )
62. Cui L,Liu B,Liu GP, et al. Repair of cranial bone defects with adipose derived stem cells and coral scaffold in a canine model. Biomaterials. 2007; 28:5477-5486. (IF 7.8)
63. Jiang XG, Ye ML, Jiang XM, et al. Exploring the bone proteome: from protein identification to protein function. Method development of efficient protein extraction in bone tissue for proteome analysis, J. Proteome Res.,2007,6:2287-2294. (IF: 5.6).
64. Cui L,Yin S, Liu W, Li NL, Zhang WJ, Cao YL. Expanded adipose derived stem cells suppress mixed lymphocyte reaction by secretion of prostaglandin E2. Tissue Eng, 2007; 13: 1185-95. (IF:4.5).
65. Jie Yuan, Cui L, Wen Jie Zhanga, Wei Liu,Yilin Cao. Repair of canine mandibular bone defects with bone marrow stromal cells and porous b-tricalcium phosphate. Biomaterials. 2007; 28: 1005-13. (IF 7.8).
