陈健，医学博士，胸外科副主任医师，pg游戏电子模拟器博士生导师、研究员、副教授，美国佐治亚大学访问学者。
主持国家自然科学基金2项，获评上海市科技启明星、上海市医苑新星，获得上海市科委原创探索项目（我院首个获批项目）。主持2项国家卫健委科研课题、pg游戏电子模拟器青年优秀人才项目、“医学+X”交叉研究项目及多项课题。
近年来围绕肺癌免疫调控、治疗耐药及肿瘤微环境重塑等方向持续开展研究，取得了一系列具有临床转化价值的成果，在 Genome Biology、Advanced Science、Signal Transduction and Targeted Therapy 等期刊发表多篇论文，单篇最高影响因子达52，影响因子>8的论文共7篇，累计被引用400余次。其中3篇成果入选“pg游戏电子模拟器创新成果”。曾在国内外学术会议中作特邀报告5次，参编专著4部（其中2部任副主编）。荣获2018年欧洲胸外科学会（ESTS）Travel Grant（35岁以下最佳大会报告奖）及2019年ESTS JACS Award（亚洲区域最佳论文摘要奖）。
临床方面，年手术量超过1000台，其中主刀手术每年超500台，专注于以肺癌为主的胸部肿瘤微创外科治疗及各类胸外科疾病的诊治，熟练掌握肺叶/肺段切除术及纵隔肿瘤手术等操作。曾获2022年与2025年上海市肺科医院“优秀医师”、2023年肺科胸外青年手术交流赛“风采之星”、2025年GCTAB胸腔镜手术视频大赛全国总冠军等荣誉。
代表性论文：
【1】Chen J, Tan Y,Sun F, et al. Single-cell transcriptome and antigen-immunoglobin analysisreveals the diversity of B cells in non-small cell lung cancer. GenomeBiol 2020;21(1):152. （IF=13.584）
【2】Chen J, Zhao D, Wang Y,et al. LactylatedApolipoprotein C-II Induces Immunotherapy Resistance by Promoting ExtracellularLipolysis. Adv Sci (Weinh). 2024 Oct;11(38):e2406333. （IF=14.3）
【3】Chen J, Na R,Xiao C , et al. The loss of SHMT2 mediates 5-fluorouracil chemoresistance incolorectal cancer by upregulating autophagy. Oncogene2021, 40(23): 3974-3988. （IF=9.867）
【4】Chen J, Soultanis KM, Sun FH, Gonzalez-Rivas D, et al. Outcomes of sleeve lobectomy versus pneumonectomy: A propensity score-matched study. J Thorac Cardiovasc Surg. 2021;162(6). DOI: 10.1016/j.jtcvs.2020.08.027 .（IF=5.209）
【5】Ma J, Liu Y, Xu H, Duan X, Dai Z, Guo Y, Song H, Tan Y, Chen J. Plasma proteomic profiling with machine learning identifies immunometabolic perturbations associated with smoking and smoking cessation. iScience.（IF=4.1，Accepted for publication）
【6】Wang H, Xiong A, Chen J, et al. CXCR1+ neutrophilinfiltration orchestrates response to third-generation EGFR-TKI in EGFR mutantnon-small-cell lung cancer. Signal Transduct Target Ther. 2024 Dec 6;9(1):342.（共同通讯）（IF=52.7）
【7】Jiang T, Chen J, Wang H, et al. Genomiccorrelates of the response to first-line PD-1 blockade plus chemotherapy inpatients with advanced non-small-cell lung cancer. Chin Med J (Engl). 2024 Aug21;137(18):2213–22. （IF=7.5）
Chen Jian, Doctor of Medicine, is an Associate Chief Physician in Thoracic Surgery, an Associate Professor and Research Professor, a Doctoral Supervisor at Tongji University, and a Visiting Scholar at the University of Georgia, USA.
He has led two projects funded by the National Natural Science Foundation of China and has been recognized by the Shanghai Rising-Star Program in Science and Technology and the Shanghai Medical Rising Star Program. He also received an Original Exploratory Project grant from the Shanghai Municipal Science and Technology Commission, the first such award at his hospital. In addition, he has led two research projects funded by the National Health Commission of China, the Tongji University Young Excellent Talents Program, the “Medicine + X” interdisciplinary research program, and several other projects.
In recent years, his research has focused on lung cancer immunoregulation, therapeutic resistance, and tumor microenvironment remodeling. He has published multiple papers in journals including Genome Biology, Advanced Science, and Signal Transduction and Targeted Therapy. His highest-impact publication appeared in a journal with an impact factor of 52; seven of his papers were published in journals with an impact factor above 8, and his work has been cited more than 400 times. Three of these achievements were selected as “Innovative Achievements of Tongji University.” He has delivered five invited presentations at domestic and international conferences and contributed to four academic books, serving as associate editor for two. He received the 2018 European Society of Thoracic Surgeons Travel Grant and the 2019 ESTS JACS Award for Best Abstract from Asia.
Clinically, he performs more than 1,000 operations each year, including over 500 as the primary surgeon. He specializes in minimally invasive surgery for thoracic tumors, particularly lung cancer, and in the diagnosis and treatment of thoracic diseases. He is experienced in lobectomy, segmentectomy, and mediastinal tumor surgery. His honors include “Outstanding Physician” at Shanghai Pulmonary Hospital in 2022 and 2025, “Star of Excellence” in the 2023 Youth Thoracic Surgery Skills Exchange Competition, and National Champion of the 2025 GCTAB Thoracoscopic Surgery Video Competition.
